Develop treatments for Alzheimer’s disease
According to Alzheimer diseases Disease International, about 36 million people have Alzheimer diseases or related dementia in 2014. Alzheimer disease is most common in developed countries- Western Europe and America. 1 in 9 Americans over 65 has Alzheimer disease and 5.2 million Americans are living with Alzheimer disease. The global cost of Alzheimer disease and dementia is estimated to be $605 billion. However, There are no drug treatments available that can provide a cure for Alzheimer disease yet. However, many health professionals suggest age, genetics and mineral imbalances may cause Alzheimer disease.
Many scientists suggest that Alzheimer disease may be related to calcium.Both osteoporosis and Alzheimer disease are aging associated multifactorial progressive degenerative diseases and both occur usually in seniors. According to recent scientific research, senior women who have low bone density are more than twice likely to develop Alzheimer disease. It indicates that Alzheimer disease is closely linked to osteoporosis, however, the mechanisms underlying this are unknown.
Many recent scientific research look at the connection between Alzheimer’s and the way brain cells regulate the amount of calcium they contain. Brain cells needs to maintain the right amount of calcium at any given moment and that depends on the cells responding to signals from elsewhere in the brain. One study suggests that abnormal response to these signals leads to abnormal calcium levels in brain cells, which ultimately leads to Alzheimer’s. Another study proposes that an imbalance in calcium might actually cause Alzheimer’s.Researchers found that patients who have a rare, inherited form of the disease carry genes that not only cause amyloid buildup, but also problems with calcium regulation. They all indicate the link between calcium and Alzheimer’s.
Although the cause of Alzheimer’s disease is unknown, like osteoporosis, Alzheimer’s disease is thought to be associated with the disruption of calcium homeostasis in the brain and thus. deregulation of calcium-mediated signaling.
Current treatment for Alzheimer’s have focused on preventing or eliminating the buildup of amyloid. However, new studies recommends that future treatments needs to take into consideration correct abnormal calcium levels in brain cells. So far, we found that SAC calcium helps maintain balance of calcium in the brain. We will focus on developing dietary supplement for effectively preventing Alzheimer’s diseases, including dementia.