According to WHO, Cardiovascular Disease (CVDs), mainly heart disease and stroke, is the top cause of death globally. Statistically, about 17.3 million people have died from CVDs in 2008, representing 30% of all global death, and over 80% of CVDs take place in low and middle income countries. Most CVDs can be prevented by controlling diet, tobacco use, obesity, high blood pressure, diabetes and physical activity.
Calcium plays an important role in regulating the contraction and relaxation phases of the cardiac cycle. Calcium flows into the muscle cells through tiny channels and works as a switch that allows each heart muscle fiber to slide past each other and shorten to contract. At the end of each contraction, calcium flows out of the channels to allow the muscles to relax and lengthen again. Indeed, myocardial contractility is primarily controlled by calcium cycling.
When there are calcium ion cycling defects in a heart, the heart is not able to adequately pump sufficient blood and it leads to heart failure, which is characterized by reduced calcium entry into cardiac muscle cells and decreased myofilament calcium sensitivity. Consequently, many health professionals have suggested that improvements in calcium cycling or sensitivity be a useful treatment of heart failure. Calcium also plays an important role in triggering timely and strong enough contraction in the cardiac muscle to circulate blood throughout the body.
The cardiac muscles require calcium ions to contract and squeeze blood out of the heart and into the arteries in the body. Pronuvia believes that SAC calcium plays an important role in the maintenance of cardiac function and blood circulation because SAC calcium promotes cardiac relaxation and contractility. In other words, SAC calcium helps synchronize cardiovascular muscle contraction. We are currently engaged in the study of SAC calcium’s positive influence in cardiac functions.